Tissue-Specific Methylation of Human Insulin Gene and PCR Assay for Monitoring Beta Cell Death

The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destruction of the majority of pancreatic insulin-producing beta cells. We previously demonstrated that the DNA encoding the insulin gene is uniquely unmethylated in these cells and then developed a methylation-spe...

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Detalles Bibliográficos
Autores principales: Husseiny, Mohamed I., Kaye, Alexander, Zebadua, Emily, Kandeel, Fouad, Ferreri, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983232/
https://www.ncbi.nlm.nih.gov/pubmed/24722187
http://dx.doi.org/10.1371/journal.pone.0094591

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983232/
https://www.ncbi.nlm.nih.gov/pubmed/24722187
http://dx.doi.org/10.1371/journal.pone.0094591

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