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Tissue-Specific Methylation of Human Insulin Gene and PCR Assay for Monitoring Beta Cell Death
The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destruction of the majority of pancreatic insulin-producing beta cells. We previously demonstrated that the DNA encoding the insulin gene is uniquely unmethylated in these cells and then developed a methylation-spe...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983232/ https://www.ncbi.nlm.nih.gov/pubmed/24722187 http://dx.doi.org/10.1371/journal.pone.0094591 |