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Translocation Thermodynamics of Linear and Cyclic Nonaarginine into Model DPPC Bilayer via Coarse-Grained Molecular Dynamics Simulation: Implications of Pore Formation and Nonadditivity

[Image: see text] Structural mechanisms and underlying thermodynamic determinants of efficient internalization of charged cationic peptides (cell-penetrating peptides, CPPs) such as TAT, polyarginine, and their variants, into cells, cellular constructs, and model membrane/lipid bilayers (large and g...

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Detalles Bibliográficos
Autores principales: Hu, Yuan, Liu, Xiaorong, Sinha, Sudipta Kumar, Patel, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983342/
https://www.ncbi.nlm.nih.gov/pubmed/24506488
http://dx.doi.org/10.1021/jp412600e