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Capping Amyloid β-Sheets of the Tau-Amyloid Structure VQIVYK with Hexapeptides Designed To Arrest Growth. An ONIOM and Density Functional Theory Study
[Image: see text] We present ONIOM calculations using density functional theory (DFT) as the high and AM1 as the medium level that explore the abilities of different hexapeptide sequences to terminate the growth of a model for the tau-amyloid implicated in Alzheimer’s disease. We delineate and explo...
Autores principales: | Plumley, Joshua A., Ali-Torres, Jorge, Pohl, Gabor, Dannenberg, J. J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2014
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983367/ https://www.ncbi.nlm.nih.gov/pubmed/24601594 http://dx.doi.org/10.1021/jp501890p |
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