Nitric Oxide (NO) Releasing Poly ADP-ribose Polymerase 1 (PARP-1) Inhibitors Targeted to Glutathione S-Transferase P1-Overexpressing Cancer Cells

[Image: see text] We report the antitumor effects of nitric oxide (NO) releasing derivatives of the PARP-1 inhibitor olaparib (1). Compound 5b was prepared by coupling the carboxyl group of 3b and the free amino group of arylated diazeniumdiolated piperazine 4. Analogue 5a has the same structure exc...

Descripción completa

Detalles Bibliográficos
Autores principales: Maciag, Anna E., Holland, Ryan J., Kim, Youseung, Kumari, Vandana, Luthers, Christina E., Sehareen, Waheed S., Biswas, Debanjan, Morris, Nicole L., Ji, Xinhua, Anderson, Lucy M., Saavedra, Joseph E., Keefer, Larry K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983374/
https://www.ncbi.nlm.nih.gov/pubmed/24521039
http://dx.doi.org/10.1021/jm401550d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983374/
https://www.ncbi.nlm.nih.gov/pubmed/24521039
http://dx.doi.org/10.1021/jm401550d

Ejemplares similares