Can Amphipathic Helices Influence the CNS Antinociceptive Activity of Glycopeptides Related to β-Endorphin?

[Image: see text] Glycosylated β-endorphin analogues of various amphipathicity were studied in vitro and in vivo in mice. Opioid binding affinities of the O-linked glycopeptides (mono- or disaccharides) and unglycosylated peptide controls were measured in human receptors expressed in CHO cells. All...

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Detalles Bibliográficos
Autores principales: Li, Yingxue, St. Louis, Lindsay, Knapp, Brian I., Muthu, Dhanasekaran, Anglin, Bobbi, Giuvelis, Denise, Bidlack, Jean M., Bilsky, Edward J., Polt, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983389/
https://www.ncbi.nlm.nih.gov/pubmed/24576160
http://dx.doi.org/10.1021/jm400879w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983389/
https://www.ncbi.nlm.nih.gov/pubmed/24576160
http://dx.doi.org/10.1021/jm400879w

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