Optimization of 4-(N-Cycloamino)phenylquinazolines as a Novel Class of Tubulin-Polymerization Inhibitors Targeting the Colchicine Site

[Image: see text] The 6-methoxy-1,2,3,4-tetrahydroquinoline moiety in prior leads 2-chloro- and 2-methyl-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)quinazoline (1a and 1b) was modified to produce 4-(N-cycloamino)quinazolines (4a–c and 5a–m). The new compounds were evaluated in cytotoxicity and tubuli...

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Detalles Bibliográficos
Autores principales: Wang, Xiao-Feng, Guan, Fang, Ohkoshi, Emika, Guo, Wanjun, Wang, Lili, Zhu, Dong-Qing, Wang, Sheng-Biao, Wang, Li-Ting, Hamel, Ernest, Yang, Dexuan, Li, Linna, Qian, Keduo, Morris-Natschke, Susan L., Yuan, Shoujun, Lee, Kuo-Hsiung, Xie, Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983391/
https://www.ncbi.nlm.nih.gov/pubmed/24502232
http://dx.doi.org/10.1021/jm4016526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983391/
https://www.ncbi.nlm.nih.gov/pubmed/24502232
http://dx.doi.org/10.1021/jm4016526

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