wALADin Benzimidazoles Differentially Modulate the Function of Porphobilinogen Synthase Orthologs

[Image: see text] The heme biosynthesis enzyme porphobilinogen synthase (PBGS) is a potential drug target in several human pathogens. wALADin1 benzimidazoles have emerged as species-selective PBGS inhibitors against Wolbachia endobacteria of filarial worms. In the present study, we have systematical...

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Detalles Bibliográficos
Autores principales: Lentz, Christian S., Halls, Victoria S., Hannam, Jeffrey S., Strassel, Silke, Lawrence, Sarah H., Jaffe, Eileen K., Famulok, Michael, Hoerauf, Achim, Pfarr, Kenneth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983392/
https://www.ncbi.nlm.nih.gov/pubmed/24568185
http://dx.doi.org/10.1021/jm401785n

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983392/
https://www.ncbi.nlm.nih.gov/pubmed/24568185
http://dx.doi.org/10.1021/jm401785n

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