Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow

Nitric oxide (NO) maintains cardiovascular health by activating soluble guanylate cyclase (sGC) to increase cellular cGMP levels. Cardiovascular disease is characterized by decreased NO-sGC-cGMP signaling. Pharmacological activators and stimulators of sGC are being actively pursued as therapies for...

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Autores principales: Rogers, Natasha M., Seeger, Franziska, Garcin, Elsa D., Roberts, David D., Isenberg, Jeffrey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983488/
https://www.ncbi.nlm.nih.gov/pubmed/24772092
http://dx.doi.org/10.3389/fphys.2014.00134
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author Rogers, Natasha M.
Seeger, Franziska
Garcin, Elsa D.
Roberts, David D.
Isenberg, Jeffrey S.
author_facet Rogers, Natasha M.
Seeger, Franziska
Garcin, Elsa D.
Roberts, David D.
Isenberg, Jeffrey S.
author_sort Rogers, Natasha M.
collection PubMed
description Nitric oxide (NO) maintains cardiovascular health by activating soluble guanylate cyclase (sGC) to increase cellular cGMP levels. Cardiovascular disease is characterized by decreased NO-sGC-cGMP signaling. Pharmacological activators and stimulators of sGC are being actively pursued as therapies for acute heart failure and pulmonary hypertension. Here we review molecular mechanisms that modulate sGC activity while emphasizing a novel biochemical pathway in which binding of the matricellular protein thrombospondin-1 (TSP1) to the cell surface receptor CD47 causes inhibition of sGC. We discuss the therapeutic implications of this pathway for blood flow, tissue perfusion, and cell survival under physiologic and disease conditions.
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spelling pubmed-39834882014-04-25 Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow Rogers, Natasha M. Seeger, Franziska Garcin, Elsa D. Roberts, David D. Isenberg, Jeffrey S. Front Physiol Physiology Nitric oxide (NO) maintains cardiovascular health by activating soluble guanylate cyclase (sGC) to increase cellular cGMP levels. Cardiovascular disease is characterized by decreased NO-sGC-cGMP signaling. Pharmacological activators and stimulators of sGC are being actively pursued as therapies for acute heart failure and pulmonary hypertension. Here we review molecular mechanisms that modulate sGC activity while emphasizing a novel biochemical pathway in which binding of the matricellular protein thrombospondin-1 (TSP1) to the cell surface receptor CD47 causes inhibition of sGC. We discuss the therapeutic implications of this pathway for blood flow, tissue perfusion, and cell survival under physiologic and disease conditions. Frontiers Media S.A. 2014-04-04 /pmc/articles/PMC3983488/ /pubmed/24772092 http://dx.doi.org/10.3389/fphys.2014.00134 Text en Copyright © 2014 Rogers, Seeger, Garcin, Roberts and Isenberg. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Rogers, Natasha M.
Seeger, Franziska
Garcin, Elsa D.
Roberts, David D.
Isenberg, Jeffrey S.
Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow
title Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow
title_full Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow
title_fullStr Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow
title_full_unstemmed Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow
title_short Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow
title_sort regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983488/
https://www.ncbi.nlm.nih.gov/pubmed/24772092
http://dx.doi.org/10.3389/fphys.2014.00134
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