TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli

Multiple observations suggest a cell type-specific role for TP53 in mammary epithelia. We developed an in vitro assay, in which primary mouse mammary epithelial cells (mMECs) progressed from lumenal to basal-like phenotypes based on expression of Krt18 or ΔNp63, respectively. Such transition was mar...

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Detalles Bibliográficos
Autores principales: Munne, Pauliina M., Gu, Yuexi, Tumiati, Manuela, Gao, Ping, Koopal, Sonja, Uusivirta, Sanna, Sawicki, Janet, Wei, Gong-Hong, Kuznetsov, Sergey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983616/
https://www.ncbi.nlm.nih.gov/pubmed/24722541
http://dx.doi.org/10.1038/srep04663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983616/
https://www.ncbi.nlm.nih.gov/pubmed/24722541
http://dx.doi.org/10.1038/srep04663

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