Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion

The concept of ‘field cancerization’ describes the clonal expansion of genetically altered, but morphologically normal cells that predisposes a tissue to cancer development. Here, we demonstrate that biased stem cell competition in the mouse small intestine can initiate the expansion of such clones....

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Detalles Bibliográficos
Autores principales: Snippert, Hugo J, Schepers, Arnout G, van Es, Johan H, Simons, Benjamin D, Clevers, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983678/
https://www.ncbi.nlm.nih.gov/pubmed/24355609
http://dx.doi.org/10.1002/embr.201337799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983678/
https://www.ncbi.nlm.nih.gov/pubmed/24355609
http://dx.doi.org/10.1002/embr.201337799

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