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A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis
The extrinsic apoptosis pathway is initiated by binding of death ligands to death receptors resulting in the formation of the death-inducing signaling complex (DISC). Activation of procaspase-8 within the DISC and its release from the signaling complex is required for processing executor caspases an...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Publishing Ltd
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983683/ https://www.ncbi.nlm.nih.gov/pubmed/24442637 http://dx.doi.org/10.1002/embj.201385686 |