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A synthetic lethal screen identifies FAT1 as an antagonist of caspase-8 in extrinsic apoptosis

The extrinsic apoptosis pathway is initiated by binding of death ligands to death receptors resulting in the formation of the death-inducing signaling complex (DISC). Activation of procaspase-8 within the DISC and its release from the signaling complex is required for processing executor caspases an...

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Detalles Bibliográficos
Autores principales:	Kranz, Dominique, Boutros, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3983683/ https://www.ncbi.nlm.nih.gov/pubmed/24442637 http://dx.doi.org/10.1002/embj.201385686

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