Histone Deacetylase Inhibitors Sensitize Lung Cancer Cells to Hyperthermia: Involvement of Ku70/SirT-1 in Thermo-Protection

This study describes the sensitization mechanism to thermal stress by histone deacetylase inhibitors (HDACIs) in lung cancer cells and shows that Ku70, based on its acetylation status, mediates the protection of lung cancer from hyperthermia (42.5°C, 1-6 hrs). Ku70 regulates apoptosis by sequesterin...

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Detalles Bibliográficos
Autores principales: Hassan, Mohamed K., Watari, Hidemichi, Salah-eldin, Alaa-eldin, Sultan, Ahmed S., Mohamed, Zainab, Fujioka, Yoichiro, Ohba, Yusuke, Sakuragi, Noriaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984116/
https://www.ncbi.nlm.nih.gov/pubmed/24728004
http://dx.doi.org/10.1371/journal.pone.0094213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984116/
https://www.ncbi.nlm.nih.gov/pubmed/24728004
http://dx.doi.org/10.1371/journal.pone.0094213

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