The proteosome inhibitor MG132 attenuates Retinoic Acid Receptor trans-activation and enhances trans-repression of Nuclear Factor κB. Potential relevance to chemo-preventive interventions with retinoids

BACKGROUND: Nuclear factor kappa B (NFκB) is a pro-malignant transcription factor with reciprocal effects on pro-metastatic and anti-metastatic gene expression. Interestingly, NFκB blockade results in the reciprocal induction of retinoic acid receptors (RARs). Given the established property of RARs...

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Detalles Bibliográficos
Autores principales: Andela, Valentine B, Rosier, Randy N
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC398417/
https://www.ncbi.nlm.nih.gov/pubmed/15035668
http://dx.doi.org/10.1186/1476-4598-3-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC398417/
https://www.ncbi.nlm.nih.gov/pubmed/15035668
http://dx.doi.org/10.1186/1476-4598-3-8

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