TRF2 Interaction with Ku Heterotetramerization Interface Gives Insight into c-NHEJ Prevention at Human Telomeres

Telomeres are protected from nonhomologous end-joining (NHEJ) to avoid deleterious chromosome fusions, yet they associate with the Ku heterodimer that is principal in the classical NHEJ (c-NHEJ) pathway. T-loops have been proposed to inhibit Ku’s association with telomeric ends, thus inhibiting c-NH...

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Detalles Bibliográficos
Autores principales: Ribes-Zamora, Albert, Indiviglio, Sandra M., Mihalek, Ivana, Williams, Christopher L., Bertuch, Alison A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984498/
https://www.ncbi.nlm.nih.gov/pubmed/24095731
http://dx.doi.org/10.1016/j.celrep.2013.08.040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984498/
https://www.ncbi.nlm.nih.gov/pubmed/24095731
http://dx.doi.org/10.1016/j.celrep.2013.08.040

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