Synthesis and Gene Silencing Properties of siRNAs Containing Terminal Amide Linkages

The active components of the RNAi are 21 nucleotides long dsRNAs containing a 2 nucleotide overhang at the 3′ end, carrying 5′-phosphate and 3′-hydroxyl groups (siRNAs). Structural analysis revealed that the siRNA is functionally bound at both ends to RISC. Terminal modifications are considered with...

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Detalles Bibliográficos
Autores principales: Gaglione, Maria, Mercurio, M. Emilia, Potenza, Nicoletta, Mosca, Nicola, Russo, Aniello, Novellino, Ettore, Cosconati, Sandro, Messere, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984766/
https://www.ncbi.nlm.nih.gov/pubmed/24791003
http://dx.doi.org/10.1155/2014/901617

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984766/
https://www.ncbi.nlm.nih.gov/pubmed/24791003
http://dx.doi.org/10.1155/2014/901617

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