Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells

Oncogenic mutations in PIK3CA lead to an increase in intrinsic phosphoinositide kinase activity, but it is thought that increased access of PI3Kα (phosphoinositide 3-kinase α) to its PM (plasma membrane) localized substrate is also required for increased levels of downstream PIP(3)/Akt [phosphoinosi...

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Detalles Bibliográficos
Autores principales: Layton, Meredith J., Rynkiewicz, Natalie K., Ivetac, Ivan, Horan, Kristy A., Mitchell, Christina A., Phillips, Wayne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985441/
https://www.ncbi.nlm.nih.gov/pubmed/27919038
http://dx.doi.org/10.1042/BSR20130133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985441/
https://www.ncbi.nlm.nih.gov/pubmed/27919038
http://dx.doi.org/10.1042/BSR20130133

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