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Quality Matters: Extension of Clusters of Residues with Good Hydrophobic Contacts Stabilize (Hyper)Thermophilic Proteins

[Image: see text] Identifying determinant(s) of protein thermostability is key for rational and data-driven protein engineering. By analyzing more than 130 pairs of mesophilic/(hyper)thermophilic proteins, we identified the quality (residue-wise energy) of hydrophobic interactions as a key factor fo...

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Detalles Bibliográficos
Autores principales: Rathi, Prakash Chandra, Höffken, Hans Wolfgang, Gohlke, Holger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985445/
https://www.ncbi.nlm.nih.gov/pubmed/24437522
http://dx.doi.org/10.1021/ci400568c