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High Temperature SELMA: Evolution of DNA-Supported Oligomannose Clusters Which Are Tightly Recognized by HIV bnAb 2G12

[Image: see text] SELMA (SELection with Modified Aptamers) is a directed evolution method which can be used to develop DNA-supported clusters of carbohydrates in which the geometry of clustering is optimized for strong recognition by a lectin of interest. Herein, we report a modification of SELMA wh...

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Detalles Bibliográficos
Autores principales: Temme, J. Sebastian, MacPherson, Iain S., DeCourcey, John F., Krauss, Isaac J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985446/
https://www.ncbi.nlm.nih.gov/pubmed/24446826
http://dx.doi.org/10.1021/ja411212q