Crystal Structure of DNA Polymerase β with DNA Containing the Base Lesion Spiroiminodihydantoin in a Templating Position

[Image: see text] The first high-resolution crystal structure of spiroiminodihydantoin (dSp1) was obtained in the context of the DNA polymerase β active site and reveals two areas of significance. First, the structure verifies the recently determined S configuration at the spirocyclic carbon. Second...

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Detalles Bibliográficos
Autores principales: Eckenroth, Brian E., Fleming, Aaron M., Sweasy, Joann B., Burrows, Cynthia J., Doublié, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985455/
https://www.ncbi.nlm.nih.gov/pubmed/24649945
http://dx.doi.org/10.1021/bi500270e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985455/
https://www.ncbi.nlm.nih.gov/pubmed/24649945
http://dx.doi.org/10.1021/bi500270e

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