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Grubbs Cross-Metathesis Pathway for a Scalable Synthesis of γ-Keto-α,β-unsaturated Esters
[Image: see text] A direct and scalable route to γ-keto-α,β-unsaturated esters, useful intermediates in medicinal chemistry and natural products synthesis, is reported. The key step involves the use of Grubbs’ second-generation olefin metathesis catalyst for cross-metathesis of alkyl acrylates and 2...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985456/ https://www.ncbi.nlm.nih.gov/pubmed/24393145 http://dx.doi.org/10.1021/jo4023606 |