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Calcium Inhibition of Ribonuclease H1 Two-Metal Ion Catalysis
[Image: see text] Most phosphate-processing enzymes require Mg(2+) as a cofactor to catalyze nucleotide cleavage and transfer reactions. Ca(2+) ions inhibit many of these enzymatic activities, despite Ca(2+) and Mg(2+) having comparable binding affinities and overall biological abundances. Here we s...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985467/ https://www.ncbi.nlm.nih.gov/pubmed/24499076 http://dx.doi.org/10.1021/ja411408x |