Stepwise assembly of multiple Lin28 proteins on the terminal loop of let-7 miRNA precursors

Lin28 inhibits the biogenesis of let-7 miRNAs through direct interactions with let-7 precursors. Previous studies have described seemingly inconsistent Lin28 binding sites on pre-let-7 RNAs. Here, we reconcile these data by examining the binding mechanism of Lin28 to the terminal loop of pre-let-7g...

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Detalles Bibliográficos
Autores principales: Desjardins, Alexandre, Bouvette, Jonathan, Legault, Pascale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985620/
https://www.ncbi.nlm.nih.gov/pubmed/24452802
http://dx.doi.org/10.1093/nar/gkt1391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985620/
https://www.ncbi.nlm.nih.gov/pubmed/24452802
http://dx.doi.org/10.1093/nar/gkt1391

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