MLV integration site selection is driven by strong enhancers and active promoters

Retroviruses integrate into the host genome in patterns specific to each virus. Understanding the causes of these patterns can provide insight into viral integration mechanisms, pathology and genome evolution, and is critical to the development of safe gene therapy vectors. We generated murine leuke...

Descripción completa

Detalles Bibliográficos
Autores principales: LaFave, Matthew C., Varshney, Gaurav K., Gildea, Derek E., Wolfsberg, Tyra G., Baxevanis, Andreas D., Burgess, Shawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985626/
https://www.ncbi.nlm.nih.gov/pubmed/24464997
http://dx.doi.org/10.1093/nar/gkt1399

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985626/
https://www.ncbi.nlm.nih.gov/pubmed/24464997
http://dx.doi.org/10.1093/nar/gkt1399

Ejemplares similares