The crystal structure of TDP-43 RRM1-DNA complex reveals the specific recognition for UG- and TG-rich nucleic acids

TDP-43 is an important pathological protein that aggregates in the diseased neuronal cells and is linked to various neurodegenerative disorders. In normal cells, TDP-43 is primarily an RNA-binding protein; however, how the dimeric TDP-43 binds RNA via its two RNA recognition motifs, RRM1 and RRM2, i...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuo, Pan-Hsien, Chiang, Chien-Hao, Wang, Yi-Ting, Doudeva, Lyudmila G., Yuan, Hanna S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985631/
https://www.ncbi.nlm.nih.gov/pubmed/24464995
http://dx.doi.org/10.1093/nar/gkt1407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985631/
https://www.ncbi.nlm.nih.gov/pubmed/24464995
http://dx.doi.org/10.1093/nar/gkt1407

Ejemplares similares