The influence of CpG and UpA dinucleotide frequencies on RNA virus replication and characterization of the innate cellular pathways underlying virus attenuation and enhanced replication

Most RNA viruses infecting mammals and other vertebrates show profound suppression of CpG and UpA dinucleotide frequencies. To investigate this functionally, mutants of the picornavirus, echovirus 7 (E7), were constructed with altered CpG and UpA compositions in two 1.1–1.3 Kbase regions. Those with...

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Detalles Bibliográficos
Autores principales: Atkinson, Nicky J., Witteveldt, Jeroen, Evans, David J., Simmonds, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985648/
https://www.ncbi.nlm.nih.gov/pubmed/24470146
http://dx.doi.org/10.1093/nar/gku075

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985648/
https://www.ncbi.nlm.nih.gov/pubmed/24470146
http://dx.doi.org/10.1093/nar/gku075

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