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The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells
As proliferating cells transit from interphase into M-phase, chromatin undergoes extensive reorganization, and topoisomerase (topo) IIα, the major isoform of this enzyme present in cycling vertebrate cells, plays a key role in this process. In this study, a human cell line conditional null mutant fo...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985649/ https://www.ncbi.nlm.nih.gov/pubmed/24476913 http://dx.doi.org/10.1093/nar/gku076 |