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The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells

As proliferating cells transit from interphase into M-phase, chromatin undergoes extensive reorganization, and topoisomerase (topo) IIα, the major isoform of this enzyme present in cycling vertebrate cells, plays a key role in this process. In this study, a human cell line conditional null mutant fo...

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Detalles Bibliográficos
Autores principales:	Farr, Christine J., Antoniou-Kourounioti, Melissa, Mimmack, Michael L., Volkov, Arsen, Porter, Andrew C. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985649/ https://www.ncbi.nlm.nih.gov/pubmed/24476913 http://dx.doi.org/10.1093/nar/gku076

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