S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection

Insertional oncogene activation and aberrant splicing have proved to be major setbacks for retroviral stem cell gene therapy. Integrase-deficient human immunodeficiency virus-1-derived vectors provide a potentially safer approach, but their circular genomes are rapidly lost during cell division. Her...

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Detalles Bibliográficos
Autores principales: Verghese, Santhosh Chakkaramakkil, Goloviznina, Natalya A., Skinner, Amy M., Lipps, Hans J., Kurre, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985655/
https://www.ncbi.nlm.nih.gov/pubmed/24474068
http://dx.doi.org/10.1093/nar/gku082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985655/
https://www.ncbi.nlm.nih.gov/pubmed/24474068
http://dx.doi.org/10.1093/nar/gku082

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