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S/MAR sequence confers long-term mitotic stability on non-integrating lentiviral vector episomes without selection
Insertional oncogene activation and aberrant splicing have proved to be major setbacks for retroviral stem cell gene therapy. Integrase-deficient human immunodeficiency virus-1-derived vectors provide a potentially safer approach, but their circular genomes are rapidly lost during cell division. Her...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985655/ https://www.ncbi.nlm.nih.gov/pubmed/24474068 http://dx.doi.org/10.1093/nar/gku082 |