Concise Enantiospecific Total Synthesis of Tubingensin A

[Image: see text] We report the enantiospecific total synthesis of (+)-tubingensin A. Our synthesis features an aryne cyclization to efficiently introduce the vicinal quaternary stereocenters of the natural product and proceeds in only nine steps (longest linear sequence) from known compounds.

Detalles Bibliográficos
Autores principales: Goetz, Adam E., Silberstein, Amanda L., Corsello, Michael A., Garg, Neil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985696/
https://www.ncbi.nlm.nih.gov/pubmed/24524351
http://dx.doi.org/10.1021/ja501142e
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author Goetz, Adam E.
Silberstein, Amanda L.
Corsello, Michael A.
Garg, Neil K.
author_facet Goetz, Adam E.
Silberstein, Amanda L.
Corsello, Michael A.
Garg, Neil K.
author_sort Goetz, Adam E.
collection PubMed
description [Image: see text] We report the enantiospecific total synthesis of (+)-tubingensin A. Our synthesis features an aryne cyclization to efficiently introduce the vicinal quaternary stereocenters of the natural product and proceeds in only nine steps (longest linear sequence) from known compounds.
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spelling pubmed-39856962015-02-14 Concise Enantiospecific Total Synthesis of Tubingensin A Goetz, Adam E. Silberstein, Amanda L. Corsello, Michael A. Garg, Neil K. J Am Chem Soc [Image: see text] We report the enantiospecific total synthesis of (+)-tubingensin A. Our synthesis features an aryne cyclization to efficiently introduce the vicinal quaternary stereocenters of the natural product and proceeds in only nine steps (longest linear sequence) from known compounds. American Chemical Society 2014-02-14 2014-02-26 /pmc/articles/PMC3985696/ /pubmed/24524351 http://dx.doi.org/10.1021/ja501142e Text en Copyright © 2014 American Chemical Society
spellingShingle Goetz, Adam E.
Silberstein, Amanda L.
Corsello, Michael A.
Garg, Neil K.
Concise Enantiospecific Total Synthesis of Tubingensin A
title Concise Enantiospecific Total Synthesis of Tubingensin A
title_full Concise Enantiospecific Total Synthesis of Tubingensin A
title_fullStr Concise Enantiospecific Total Synthesis of Tubingensin A
title_full_unstemmed Concise Enantiospecific Total Synthesis of Tubingensin A
title_short Concise Enantiospecific Total Synthesis of Tubingensin A
title_sort concise enantiospecific total synthesis of tubingensin a
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985696/
https://www.ncbi.nlm.nih.gov/pubmed/24524351
http://dx.doi.org/10.1021/ja501142e
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AT silbersteinamandal conciseenantiospecifictotalsynthesisoftubingensina
AT corsellomichaela conciseenantiospecifictotalsynthesisoftubingensina
AT gargneilk conciseenantiospecifictotalsynthesisoftubingensina

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