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Epigenetic Modification, Dehydration, and Molecular Crowding Effects on the Thermodynamics of i-Motif Structure Formation from C-Rich DNA

[Image: see text] DNA sequences with the potential to form secondary structures such as i-motifs (iMs) and G-quadruplexes (G4s) are abundant in the promoters of several oncogenes and, in some instances, are known to regulate gene expression. Recently, iM-forming DNA strands have also been employed a...

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Detalles Bibliográficos
Autores principales: Bhavsar-Jog, Yogini P., Van Dornshuld, Eric, Brooks, Tracy A., Tschumper, Gregory S., Wadkins, Randy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985701/
https://www.ncbi.nlm.nih.gov/pubmed/24564458
http://dx.doi.org/10.1021/bi401523b