HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity

BACKGROUND: Acetaminophen (APAP) hepatotoxicity is associated with a high rate of gram-negative enteric bacterial infection; however, the underlying mechanism is still unknown. APAP overdose induces massive hepatocyte necrosis, necrotic tissue releases high mobility group B1 (HMGB1) and exogenous HM...

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Detalles Bibliográficos
Autores principales: Yang, Runkuan, Zou, Xiaoping, Tenhunen, Jyrki, Zhu, Shengtao, Kajander, Henri, Koskinen, Marja-Leena, Tonnessen, Tor Inge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985724/
https://www.ncbi.nlm.nih.gov/pubmed/24708589
http://dx.doi.org/10.1186/1471-230X-14-66

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985724/
https://www.ncbi.nlm.nih.gov/pubmed/24708589
http://dx.doi.org/10.1186/1471-230X-14-66

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