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Binding of Copper and Silver to Single-Site Variants of Peptidylglycine Monooxygenase Reveals the Structure and Chemistry of the Individual Metal Centers

[Image: see text] Peptidylglycine monooxygenase (PHM) catalyzes the final step in the biosynthesis of amidated peptides that serve as important signaling molecules in numerous endocrine pathways. The catalytic mechanism has attracted much attention because of a number of unique attributes, including...

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Detalles Bibliográficos
Autores principales: Chauhan, Shefali, Kline, Chelsey D., Mayfield, Mary, Blackburn, Ninian J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985755/
https://www.ncbi.nlm.nih.gov/pubmed/24471980
http://dx.doi.org/10.1021/bi4015264