Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase

[Image: see text] The class I terpenoid cyclase epi-isozizaene synthase (EIZS) utilizes the universal achiral isoprenoid substrate, farnesyl diphosphate, to generate epi-isozizaene as the predominant sesquiterpene cyclization product and at least five minor sesquiterpene products, making EIZS an ide...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Ruiqiong, Chou, Wayne K. W., Himmelberger, Julie A., Litwin, Kevin M., Harris, Golda G., Cane, David E., Christianson, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985761/
https://www.ncbi.nlm.nih.gov/pubmed/24517311
http://dx.doi.org/10.1021/bi401643u

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985761/
https://www.ncbi.nlm.nih.gov/pubmed/24517311
http://dx.doi.org/10.1021/bi401643u

Ejemplares similares