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Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase

[Image: see text] The class I terpenoid cyclase epi-isozizaene synthase (EIZS) utilizes the universal achiral isoprenoid substrate, farnesyl diphosphate, to generate epi-isozizaene as the predominant sesquiterpene cyclization product and at least five minor sesquiterpene products, making EIZS an ide...

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Detalles Bibliográficos
Autores principales:	Li, Ruiqiong, Chou, Wayne K. W., Himmelberger, Julie A., Litwin, Kevin M., Harris, Golda G., Cane, David E., Christianson, David W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985761/ https://www.ncbi.nlm.nih.gov/pubmed/24517311 http://dx.doi.org/10.1021/bi401643u

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