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Reaction Dynamics of ATP Hydrolysis Catalyzed by P-Glycoprotein
[Image: see text] P-glycoprotein (P-gp) is a member of the ABC transporter family that confers drug resistance to many tumors by catalyzing their efflux, and it is a major component of drug–drug interactions. P-gp couples drug efflux with ATP hydrolysis by coordinating conformational changes in the...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American
Chemical Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985762/ https://www.ncbi.nlm.nih.gov/pubmed/24506763 http://dx.doi.org/10.1021/bi401280v |