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Reaction Dynamics of ATP Hydrolysis Catalyzed by P-Glycoprotein

[Image: see text] P-glycoprotein (P-gp) is a member of the ABC transporter family that confers drug resistance to many tumors by catalyzing their efflux, and it is a major component of drug–drug interactions. P-gp couples drug efflux with ATP hydrolysis by coordinating conformational changes in the...

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Detalles Bibliográficos
Autores principales:	Scian, Michele, Acchione, Mauro, Li, Mavis, Atkins, William M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985762/ https://www.ncbi.nlm.nih.gov/pubmed/24506763 http://dx.doi.org/10.1021/bi401280v

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