Molecular Recognition of Fluorine Impacts Substrate Selectivity in the Fluoroacetyl-CoA Thioesterase FlK

[Image: see text] The fluoroacetate-producing bacterium Streptomyces cattleya has evolved a fluoroacetyl-CoA thioesterase (FlK) that exhibits a remarkably high level of discrimination for its cognate substrate compared to the cellularly abundant analogue acetyl-CoA, which differs only by the absence...

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Detalles Bibliográficos
Autores principales: Weeks, Amy M., Keddie, Neil S., Wadoux, Rudy D. P., O’Hagan, David, Chang, Michelle C. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985765/
https://www.ncbi.nlm.nih.gov/pubmed/24635371
http://dx.doi.org/10.1021/bi4015049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985765/
https://www.ncbi.nlm.nih.gov/pubmed/24635371
http://dx.doi.org/10.1021/bi4015049

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