Resonance Raman Spectroscopy of the Oxygenated Intermediates of Human CYP19A1 Implicates a Compound I Intermediate in the Final Lyase Step

[Image: see text] CYP19A1, or aromatase, a cytochrome P450 responsible for estrogen biosynthesis in humans, is an important therapeutic target for the treatment of breast cancer. There is still controversy surrounding the identity of reaction intermediate that catalyzes carbon–carbon scission in thi...

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Detalles Bibliográficos
Autores principales: Mak, Piotr J., Luthra, Abhinav, Sligar, Stephen G., Kincaid, James R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985783/
https://www.ncbi.nlm.nih.gov/pubmed/24645879
http://dx.doi.org/10.1021/ja500054c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985783/
https://www.ncbi.nlm.nih.gov/pubmed/24645879
http://dx.doi.org/10.1021/ja500054c

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