Crystal Structures of Type I Dehydroquinate Dehydratase in Complex with Quinate and Shikimate Suggest a Novel Mechanism of Schiff Base Formation

[Image: see text] A component of the shikimate biosynthetic pathway, dehydroquinate dehydratase (DHQD) catalyzes the dehydration of 3-dehydroquniate (DHQ) to 3-dehydroshikimate. In the type I DHQD reaction mechanism a lysine forms a Schiff base intermediate with DHQ. The Schiff base acts as an elect...

Descripción completa

Detalles Bibliográficos
Autores principales: Light, Samuel H., Antanasijevic, Aleksandar, Krishna, Sankar N., Caffrey, Michael, Anderson, Wayne F., Lavie, Arnon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985847/
https://www.ncbi.nlm.nih.gov/pubmed/24437575
http://dx.doi.org/10.1021/bi4015506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985847/
https://www.ncbi.nlm.nih.gov/pubmed/24437575
http://dx.doi.org/10.1021/bi4015506

Ejemplares similares