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Crystal Structures of Type I Dehydroquinate Dehydratase in Complex with Quinate and Shikimate Suggest a Novel Mechanism of Schiff Base Formation

[Image: see text] A component of the shikimate biosynthetic pathway, dehydroquinate dehydratase (DHQD) catalyzes the dehydration of 3-dehydroquniate (DHQ) to 3-dehydroshikimate. In the type I DHQD reaction mechanism a lysine forms a Schiff base intermediate with DHQ. The Schiff base acts as an elect...

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Detalles Bibliográficos
Autores principales:	Light, Samuel H., Antanasijevic, Aleksandar, Krishna, Sankar N., Caffrey, Michael, Anderson, Wayne F., Lavie, Arnon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985847/ https://www.ncbi.nlm.nih.gov/pubmed/24437575 http://dx.doi.org/10.1021/bi4015506

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