Identification of Charge Transfer Transitions Related to Thiamin-Bound Intermediates on Enzymes Provides a Plethora of Signatures Useful in Mechanistic Studies

[Image: see text] Identification of enzyme-bound intermediates via their spectroscopic signatures, which then allows direct monitoring of the kinetic fate of these intermediates, poses a continuing challenge. As an electrophilic covalent catalyst, the thiamin diphosphate (ThDP) coenzyme forms a numb...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Hetalben, Nemeria, Natalia S., Andrews, Forest H., McLeish, Michael J., Jordan, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985856/
https://www.ncbi.nlm.nih.gov/pubmed/24628377
http://dx.doi.org/10.1021/bi4015743

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985856/
https://www.ncbi.nlm.nih.gov/pubmed/24628377
http://dx.doi.org/10.1021/bi4015743

Ejemplares similares