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Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles
Self-amplifying RNA or RNA replicon is a form of nucleic acid-based vaccine derived from either positive-strand or negative-strand RNA viruses. The gene sequences encoding structural proteins in these RNA viruses are replaced by mRNA encoding antigens of interest as well as by RNA polymerase for rep...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986288/ https://www.ncbi.nlm.nih.gov/pubmed/24748793 http://dx.doi.org/10.2147/IJN.S39810 |