Enhancement of CYP3A4 Activity in Hep G2 Cells by Lentiviral Transfection of Hepatocyte Nuclear Factor-1 Alpha

Human hepatoma cell lines are commonly used as alternatives to primary hepatocytes for the study of drug metabolism in vitro. However, the phase I cytochrome P450 (CYP) enzyme activities in these cell lines occur at a much lower level than their corresponding activities in primary hepatocytes, and t...

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Detalles Bibliográficos
Autores principales: Chiang, Tsai-Shin, Yang, Kai-Chiang, Chiou, Ling-Ling, Huang, Guan-Tarn, Lee, Hsuan-Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986372/
https://www.ncbi.nlm.nih.gov/pubmed/24733486
http://dx.doi.org/10.1371/journal.pone.0094885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986372/
https://www.ncbi.nlm.nih.gov/pubmed/24733486
http://dx.doi.org/10.1371/journal.pone.0094885

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