Telomerase Protects Werner Syndrome Lineage-Specific Stem Cells from Premature Aging

Werner syndrome (WS) patients exhibit premature aging predominantly in mesenchyme-derived tissues, but not in neural lineages, a consequence of telomere dysfunction and accelerated senescence. The cause of this lineage-specific aging remains unknown. Here, we document that reprogramming of WS fibrob...

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Detalles Bibliográficos
Autores principales: Cheung, Hoi-Hung, Liu, Xiaozhuo, Canterel-Thouennon, Lucile, Li, Lu, Edmonson, Catherine, Rennert, Owen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986587/
https://www.ncbi.nlm.nih.gov/pubmed/24749076
http://dx.doi.org/10.1016/j.stemcr.2014.02.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986587/
https://www.ncbi.nlm.nih.gov/pubmed/24749076
http://dx.doi.org/10.1016/j.stemcr.2014.02.006

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