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Mouse SCNT ESCs Have Lower Somatic Mutation Load Than Syngeneic iPSCs
Ectopic expression of reprogramming factors has been widely adopted to reprogram somatic nucleus into a pluripotent state (induced pluripotent stem cells [iPSCs]). However, genetic aberrations such as somatic gene mutation in the resulting iPSCs have raised concerns regarding their clinical utility....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986627/ https://www.ncbi.nlm.nih.gov/pubmed/24749065 http://dx.doi.org/10.1016/j.stemcr.2014.02.005 |