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DNA methylation subgroups and the CpG island methylator phenotype in gastric cancer: a comprehensive profiling approach
BACKGROUND: Methylation-induced silencing of promoter CpG islands in tumor suppressor genes plays an important role in human carcinogenesis. In colorectal cancer, the CpG island methylator phenotype (CIMP) is defined as widespread and elevated levels of DNA methylation and CIMP+ tumors have distinct...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986689/ https://www.ncbi.nlm.nih.gov/pubmed/24674026 http://dx.doi.org/10.1186/1471-230X-14-55 |