Amplification of Mdmx and overexpression of MDM2 contribute to mammary carcinogenesis by substituting for p53 mutations

BACKGROUND: The p53 tumor suppressor gene is mutated or deleted in nearly half of human cancers. The murine double minute 2 (Mdm2) and Mdmx represent two important cellular regulators of p53. The aim of this study was to evaluate the abnormalities of p53, Mdmx and Mdm2 genes in archived breast cance...

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Detalles Bibliográficos
Autores principales: Yu, Qiong, Li, Yan, Mu, Kun, Li, Zhishuang, Meng, Qingyong, Wu, Xiaojuan, Wang, Yan, Li, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986947/
https://www.ncbi.nlm.nih.gov/pubmed/24667108
http://dx.doi.org/10.1186/1746-1596-9-71

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986947/
https://www.ncbi.nlm.nih.gov/pubmed/24667108
http://dx.doi.org/10.1186/1746-1596-9-71

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